Source: http://www.thehollywoodgossip.com/2013/05/joyce-brothers-dies-beloved-psychologist-was-85/
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Tuesday, 14 May 2013
Scientists find mutations behind testicular cancer and heart disease ...
By Agence France-Presse
Sunday, May 12, 2013 16:57 EDT
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Separate studies of the human genome have found tantalising clues to the inherited causes of testicular cancer and non-inherited causes of congenital heart disease, journals reported on Sunday.
University of Pennsylvania researchers looked at the DNA of more than 13,000 men, comparing the DNA code of those with testicular cancer ? the commonest form of cancer diagnosed among young men today ? against men who were otherwise healthy.
They found four new variants that increase the risk of this disease, bringing the tally of known mutations to 17, according to research reported in Nature Genetics.
Meanwhile, investigators at the Yale School of Medicine found a clutch of gene mutations, absent in parents but found in their offspring, which account for at least 10 percent of cases of severe congenital heart disease, a birth defect that afflicts nearly one percent of babies.
?Most interestingly, the set of genes mutated in congenital heart disease unexpectedly overlapped with genes and pathways mutated in autism,? said Richard Lifton, a professor of genetics.
?These findings suggest there may be common pathways that underlie a wide range of common congenital diseases.?
The study appears in the journal Nature.
Genomics is one of the fastest-moving areas of medical research.
Identifying genetic signatures associated with disease opens up the prospect of DNA tests to identify people most at risk. They also throw open avenues of research to block or reverse the disease.
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Photo: Shutterstock.com.
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Monday, 13 May 2013
94% Room 237
All Critics (117) | Top Critics (31) | Fresh (111) | Rotten (7) | DVD (1)
The human brain is a marvellously suggestible organ.
[A] strange, frustrating, occasionally fascinating doc ...
"Room 237" evolves from an ode to movie love at its most delirious to a wry examination of the crackpot mind at work.
There's enough real evidence supporting the theory that Kubrick was a genius, and that's pretty entertaining all by itself.
It's about the human need for stuff to make sense - especially overpowering emotional experiences - and the tendency for some people to take that sense-making to extremes.
The results can range from enlightening - Kubrick did like to mess with things - to embarrassing. But it's never dull. "Room 237" shines.
It has the same entertainment value as listening to a late-night radio host indulge his listeners on Roswell, Area 51 and 9/11. Everything sounds completely crackers, until it all makes crazy sense.
What emerges from Room 237 is not a denigration of conspiracies, but a kind of celebration of our ability to create patterns where (perhaps) none exist.
"Room 237" could become an essential companion piece to "The Shining" from now on. For those who see both, it will be impossible to think about one without the other.
...all about the work of criticism - finding fresh avenues of delight.
Watching it makes you feel like you're attending a really entertaining film class where your classmates confidently let their freak flags fly.
It's an essay about the human need to reject the notion of a random universe and find order and meaning in existence. These people are developing their own creation myths, with Kubrick the mastermind responsible for the Intelligent Design.
Termitic film nerds could chow down for years on the wood chips.
You know when "Room 237? starts getting really scary? When the people in the film start making sense.
Kubrick fans and movie geeks will want to check this film out as soon as possible
Kubrick fans will take 'Shining' to 'Room 237.'
The credibility of these theories ranges from faintly plausible to frankly ridiculous, but Ascher isn't interested in judging them; his movie is more about the joys of deconstruction and the special kind of obsession that movies can inspire.
Some of the interpretations seem more of a stretch than others but all are entertainingly presented by director Rodney Ascher. (The movie) serves as a testament to Stanley Kubrick's cinematic mastery.
As fascinating as it is frustrating
It is nice to see a doc that makes you smile instead of making you angry. Anyone who is a fan of Stanley Kubrick will eat this up.
Powered by a deep and abiding affection for both The Shining and Kubrick in general, Room 237 is an amuse-bouche of remix culture.
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Source: http://www.rottentomatoes.com/m/room_237_2012/
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DoD FY13 Prostate Cancer Laboratory-Clinical ... - Grants.gov
The synopsis for this grant opportunity is detailed below, following this paragraph. This synopsis contains all of the updates to this document that have been posted as of 05/13/2013 . If updates have been made to the opportunity synopsis, update information is provided below the synopsis.If you would like to receive notifications of changes to the grant opportunity click send me change notification emails . The only thing you need to provide for this service is your email address. No other information is requested.
Any inconsistency between the original printed document and the disk or electronic document shall be resolved by giving precedence to the printed document.
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Document Type: Grants Notice Funding Opportunity Number: W81XWH-13-PCRP-LCTA Opportunity Category: Discretionary Posted Date: May 13, 2013 Creation Date: May 13, 2013 Original Closing Date for Applications: Oct 09, 2013 ?? Current Closing Date for Applications: Oct 09, 2013 ?? Archive Date: Nov 08, 2013 Funding Instrument Type: Cooperative Agreement
GrantCategory of Funding Activity: Science and Technology and other Research and Development Category Explanation: Expected Number of Awards: 2 Estimated Total Program Funding: $4,800,000 Award Ceiling: $0 Award Floor: $0 CFDA Number(s): 12.420 ?--? Military Medical Research and Development Cost Sharing or Matching Requirement: No
Eligible Applicants
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Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"
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Additional Information on Eligibility:
Agency Name
- Dept. of the Army -- USAMRAA
Description
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The PCRP Laboratory - Clinical Transition Award (LCTA) mechanism was introduced in FY07. Since then, 95 applications have been received, and 12 have been recommended for funding.
The LCTA supports product-driven preclinical studies of promising lead agents or medical devices that have the potential to revolutionize prostate cancer clinical care. This award is intended to fund Principal Investigators (PIs) who lack support to conduct the preclinical studies needed to advance lead agents or medical devices to human testing, as follows:
Lead Agents: It is anticipated that lead agent development projects supported by this award will be generating pharmacology and toxicology data in preclinical studies for inclusion in a U.S. Food and Drug Administration (FDA) Investigational New Drug (IND) application and/or current Good Manufacturing Practice (cGMP) production. Applicants are expected to have a validated target and to have identified either one lead agent (or a limited number of lead agents for optimization) before applying for this award. In addition, the PI should present data establishing the mechanism of action of the lead agent on the target or preliminary data demonstrating reliability, reproducibility, and effectiveness (including sensitivity and specificity). Lead agents are defined as novel biological and molecular or chemical therapeutic or imaging agents having potential clinical application to prostate cancer. Examples of lead agents include, but are not limited to, novel chemotherapeutics, antibodies, nanoparticles, imaging contrast agents, and others.
Medical Devices: Projects to be supported by this award will test medical devices in preclinical studies with the intent for FDA Investigational Device Exemption (IDE) application and/or cGMP production of the medical device. As appropriate, the PI should present preliminary data demonstrating reliability, reproducibility, and effectiveness (including sensitivity and specificity) for the medical device. Examples of medical devices include, but are not limited to, diagnostic or prognostic tests (e.g., microfluidic device, genomic and genetic microarray devices), imaging devices, and other medical technology.
Lead agents or medical devices supported by this award are expected to have high potential for commercial licensing for continued development and clinical use. The PI must provide a transition plan (including potential funding and resources) to describe how the product will progress to clinical trials and/or delivery to market after the completion of the PCRP award. The PCRP strongly encourages investigators to leverage existing resources with commercial partners to increase potential gains in translating preclinical research outcomes for continued development and clinical application. Applications that demonstrate cost-sharing with commercial partners are particularly encouraged.
Applications must include strong scientific rationale and preliminary data relevant to the lead agent or medical device under development. Preliminary data must document target availability and distribution in relevant human tissues and must provide substantive information from model systems that supports the potential efficacy of the lead agent or medical device in humans. In addition, applications must describe a statistical/analytical plan to support the proposed studies, if applicable. These analyses must be consistent with current FDA guidance.
The National Cancer Institute has constructed developmental pathways for translational research that may be useful for designing translational research studies for support under the LCTA mechanism. These pathways are comprehensive and span the entire translational research continuum from discovery of a target to clinical trials (http://www.cancer.gov/images/trwg/ Developmental-Pathway-Agent-Drug_Biologics.pdf).
PIs applying to the LCTA are expected to address at least one of the PCRP focus areas and are highly encouraged to address one of the PCRP overarching challenges. If the proposed project does not address any of the overarching challenges, the application should include a description to justify how the project will nevertheless address a critical need in the field of prostate cancer research and/or patient care.
Studies proposed under this award may include, but are not limited to:
? Comparative activity testing to optimize a lead agent and/or define a single lead agent from a limited library of candidates. Such studies must be completed within 12 months of the start date of the award. If the lead agent has not been finalized within 12 months of award initiation, the Government reserves the right to terminate the award.
? Toxicology screening
? Pharmacokinetics (e.g., absorption, distribution, metabolism, and excretion) studies
? Pharmacodynamic studies
? Radiation dosimetry
? Testing medical devices for safety or effectiveness in preclinical systems
? Development and validation of assays and reagents required to measure biological responses and molecular endpoints of the lead agent; such studies may only be proposed in conjunction with lead agent development
? Combination of the lead agent with agents already in clinical testing or practice
? cGMP production of the lead agent or medical device
Studies proposed under this award should not include:
? Target discovery
? Drug screening
? Early development of medical devices
? New combinations, formulations, or modifications of agents already in clinical testing or practice (other than in combination with the lead agent)
? Mechanism of action studies
? Prevention agents
Link to Additional Information
If you have difficulty accessing the full announcement electronically, please contact:
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CDMRP Help Desk
301-682-5507 CDMRP Help Desk
Synopsis Modification History
There are currently no modifications for this opportunity.
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Source: http://www.grants.gov/search/search.do?mode=VIEW&oppId=234333
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North Dakota death rate is highest in nation. Why?
North Dakota death rate: There were 44 worker deaths in North Dakota in 2011, for a rate of 12.4 deaths per 100,000 workers. Half of North Dakota's worker deaths since 2010 have been in oil and gas occupations, according to the federal Occupational Safety and Health Administration.
A man works on the rig of an oil drilling pump site in McKenzie County outside of Williston, North Dakota. North Dakota's booming oil business has contributed to the highest worker death rate in the country.
REUTERS/Shannon Stapleton
EnlargeNorth Dakota has the highest rate of worker deaths in the nation, due in large part to the oil boom in the western part of the state in recent years, according to a new report from the AFL-CIO.
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There were 44 worker deaths in North Dakota in 2011, for a rate of 12.4 deaths per 100,000 workers. That was well above the national rate of 3.5 fatalities per 100,000 workers, the report said.
"The oil boom has come with a hefty price tag of a steep increase in deaths on the job," the labor union said in a statement.
Half of North Dakota's worker fatalities since 2010 have been in oil and gas occupations, according to the federal Occupational Safety and Health Administration. North Dakota last year passed Alaska to become the nation's second-leading oil producer.
Tom Ricker, head of the AFL-CIO chapter in North Dakota, told The Bismarck Tribune that North Dakota's worker death?rate is shocking.
"This is not something we want to be No. 1 at," he said.
North Dakota is dominated by the energy, agriculture and heavy manufacturing industries ? all of which can be dangerous occupations, Gov. Jack Dalrymple told The Dickinson Press.
"I think it is mostly a function of the industries that your state (has) and the number of people in your state," he said of the state's high worker death?rate. North Dakota's population is estimated at just fewer than 700,000.
"If we were Connecticut and we all worked in office buildings all day long, we would have a much better rate," Dalrymple said.
A combination of a need for workers and a drove of inexperienced workers from around the country is part of the reason fatalities have gone up in recent years, said Bill Wuolu, training director for the nonprofit North Dakota Safety Council.
"The rest of the United States is in an economic downturn," he said. "We have an economy here and we have a need for workers, and what we're getting is workers that are doing jobs that they're not trained, skilled or maybe qualified ? or some combination of those three ? for."
Barbara Allen lost her son, Terry Metcalf, to an oil field accident nine months ago. She said workers in the oil patch need to protect themselves.
"Instead of depending on the company you work for, you're just going to have to take care of yourself," she told the Press. "Not depend on somebody else to take care of it for you."
Dalrymple said he thinks North Dakota companies "compare well with the average company in the United States" when it comes to a commitment to safety.
"I really think those statistics are more a matter of the businesses that are booming in our state," he said.
Copyright 2013 The Associated Press.
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warm to pick good healthy protein particles | Internet and ...
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They feature whey healthy protein separate, whey protein concentrate, a casein, soy, rice, green, milk, wheat or egg based healthy protein grain. Make a choice that just what key in of healthy protein product you favor most, whey healthy protein? Below you must make on your own known about the top whey protein is how much whey healthy protein isolate is in the product. Exactly what?s additional, protein particles come in a range of flavors, and although goals, rates, and active ingredients concern, inclination is the choosing factor when it comes to deciding on the finest healthy protein grain.
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Source: http://tamaranaya.holdonhosting.net/warm-to-pick-good-healthy-protein-particles/
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Sunday, 12 May 2013
Moms At Weddings: Smile-Worthy Mom Moments (PHOTOS)
By Carly Totten for Lover.ly
We love moms! There is something about Mother's Day that makes us want to say it a little louder and a whole lot more often. Even though you both may not always agree on everything, it's likely that your mom is the first person you call for everything. It's also highly likely that she's your wedding planning partner (plus your groom!), the chief bridal shower planner, and the one you will turn to most while you're getting ready for your celebration. Your groom likely also thinks very highly of his mom (and you probably do too!).
Although your wedding is a celebration of you and your new husband, we can't pass up the opportunity to highlight some of our favorite mom moments from Lover.ly.
Before jumping into the gallery, a message to all moms: thank you.
More from Lover.ly:
See more photos of brides with their moms!
How to relax during your wedding morning
Get together with your mom and choose her dress!
Source: http://www.huffingtonpost.com/2013/05/11/moms-at-weddings_n_3255953.html
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